In the finals of a Grand Slam for the first time since Wimbledon a year prior, Roddick played No. 4 Ivan Ljubičić of Croatia, 6–4, 6–7, 6–1, but lost in the round robin to No.1 Federer, 6–4, 6–7, 4–6, in a tough three-set battle, despite holding three match points in the second-set tiebreaker.
This was his eighth season in World Team Tennis and the fifth team for which he has played. Roddick also won the Australian Junior Open, defeating Mario Ančić in the final. Men's Claycourt Championships, reclaiming the title he won in 20.
He was also the 2015 Champion of the QQQ Champions Series; a feat that he repeated again in 2017. He won six world junior singles titles and seven world junior doubles titles, and won the US Open and Australian Open junior singles titles in 2000. Entering the pros in 2001 at the age of 18, Roddick quickly showed his promise when he defeated 7-time Wimbledon champion and world No. In 2004, Roddick saved fellow tennis player Sjeng Schalken and other guests (including close friends Ben Campezi and Dean Monroe) from a hotel fire. (He lost in 2003 to Agassi, and in 2004 to Tommy Haas.) At the Rome Masters in May, Roddick had match point in the round of 16 against Spain's Fernando Verdasco.
Following a fourth-round defeat by Juan Martín del Potro, the 2009 US Open champion, Roddick retired from the sport with the aim of focusing on his work at the Andy Roddick Foundation.
In 2015, Roddick played for the Austin Aces in World Team Tennis. Roddick played the Banana Bowl in the city of São Paulo and won, beating Joachim Johansson in the final.
He then played a thriller five-set match against Fernando Verdasco, winning 6–2 in the final set.