Elective orthopaedic populations, by contrast, permit comprehensive preoperative and premorbid cognitive assessment and CSF sampling at a clinically homogenous point, whilst still seeing a significant incidence of delirium.
The aim of the current nested case-control study was to employ a targeted quantitative metabolomic methodology to profile the CSF metabolome of patients who developed delirium following arthroplasty compared to those who did not.
Groups were compared using multivariate, univariate and receiving operator characteristic (ROC) methods.
Multivariate modelling using Orthogonal Partial Least Squares-Discriminant Analysis (OPLS-DA) of metabolomic data readily distinguished between delirium and control groups (R2 ≤ 0.56; Q2 ≤ 0.10).
Exclusion criteria included a pre-existing diagnosis of dementia or other neurodegenerative condition.