This cookie stores just a session ID; no other information is captured.Accepting the NEJM cookie is necessary to use the website.These questions have been investigated primarily in those patients with septic shock, and sufficient studies have been conducted to allow multiple meta-analyses [2–4], including a recently updated Cochrane review .
Complete data from 22 studies and partial data from 1 study were included.
Network meta-analysis provided no clear evidence that any intervention or treatment regimen is better than any other across the spectrum of outcomes.
Studies that included children and were designed to assess respiratory function in pneumonia and acute respiratory distress syndrome, as well as cross-over studies, were excluded.
Network plots were created for each outcome, and all analyses were conducted using a frequentist approach assuming a random-effects model.
There was no clear evidence that any one corticosteroid drug or treatment regimen is more likely to be effective in reducing mortality or reducing the incidence of gastrointestinal bleeding or superinfection in septic shock.